Wednesday, July 20, 2011

Lack of sperm coating plays role in infertility (AP)

WASHINGTON � Scientists have found a new contributor to male infertility, a protein that's supposed to coat sperm to help them swim to an egg, unless that coating goes missing.

About 20 percent of men may harbor gene mutations that leave their sperm coat-free and thus lower their fertility, an international research team reported Wednesday.

Today's reproductive tests can't spot the problem, said study co-author Dr. Theodore Tollner of the University of California, Davis.

"You would have no reason to think many of these men with the genetic mutation would have reduced sperm function," he said.

Anywhere from 10 percent to 15 percent of couples experience infertility, and doctors can't always find the cause. A lack of sperm or problems with their shape or ability to move explains only a fraction of infertility.

The California-led team found a new reason, a protein that's part of a family of germ-killing molecules found on the surfaces of a variety of tissues. It's secreted as sperm journey into the female reproductive tract, helping the sperm to penetrate the mucus in a woman's cervix and to avoid being tagged as an invader by her immune system.

Having two copies of a particular gene mutation means sperm cannot produce that coating. Lab tests show those sperm have a hard time making it through the mucus.

But how much does that affect fertility?

The researchers tracked 500 newly married Chinese couples attempting to conceive. The birth rate was 30 percent lower among couples with a husband who harbored that double mutation, scientists reported in the journal Science Translational Medicine.

Having just one copy of the mutated gene doesn't seem to hinder conception.

The coatless sperm don't always fail, so it's not clear just how much this issue contributes to male infertility overall.

But creating a test to diagnose these men would be easy, the researchers said. Such a test potentially would lessen the time that a couple having problems conceiving spends in limbo before trying treatments such as having sperm placed directly into the woman's uterus.

One day, a vaginal gel might even let sperm pick up the protein coating as it travels into the cervix. The California researchers say they're already trying that with animals.



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CDC: Frogs tied to salmonella being sold again (AP)

ATLANTA � A California company has resumed selling a kind of pet frog that caused salmonella illnesses in more than 240 people, most of them children. And federal health officials are not happy.

Centers for Disease Control and Prevention officials on Wednesday warned consumers that Blue Lobster Farms in June had resumed shipping African dwarf frogs from its Madera County, California, breeding facility. They say the frogs may still pose a serious health risk.

The company voluntarily stopped shipping the frogs in April, after an investigation fingered them as the source of a salmonella outbreak that sickened people nationwide over two years. No one died, but many illnesses were in children under 5 years old � some hospitalized.

Company officials could not be reached for comment.

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http://www.cdc.gov/salmonella/water-frogs-0411/

http://www.cdc.gov/media/matte/2011/05_waterfrogs.pdf



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Progress is seen on a blood test for Alzheimer's (AP)

PARIS � Scientists are closing in on a long-sought goal: A blood test to screen people for Alzheimer's disease.

An experimental test did a good job of indicating how much of the telltale Alzheimer's plaque lurks in people's brains, Australian researchers reported Wednesday. If the test proves accurate in larger studies, it could offer a way to check people having memory problems to see who needs more definitive testing for the disease.

Many blood tests are being developed and a few are used in research settings now, but only the Australian one has been validated against brain scans and other accepted diagnostic tests with good accuracy in large groups of people, said Maria Carrillo, senior director of medical and scientific relations for the Alzheimer's Association.

The results, reported Wednesday at the Alzheimer's Association International Conference in France, "give us hope that we may be able to use a blood test in the near future," although that doesn't mean next year, she said.

More than 5.4 million Americans and 35 million people worldwide have Alzheimer's, the most common form of dementia. It has no cure and drugs only temporarily ease symptoms. Finding it early allows patients and their families to prepare, and ruling it out could lead to diagnosing a more treatable cause of symptoms, such as sleep problems.

Brain scans can show signs of Alzheimer's � sticky clumps of a protein called beta amyloid � a decade or more before it causes memory and thinking problems, but scans are too expensive and impractical for routine use. Doctors and patients need simple ways to screen people for the disease.

Samantha Burnham and others at Australia's national science agency, CSIRO, working with several universities, used a long-running study of more than 1,100 people � some healthy, some impaired � to develop the blood test.

They started with blood samples from 273 study participants and identified nine hormones and proteins that seemed most predictive of amyloid levels in the brain. A cutoff level was set for what was considered high.

"The belief is that people above that point will go on to get Alzheimer's disease, and the lag is about 8 to 10 years," Burnham explained.

When researchers used the nine-marker blood test on these same participants, they found that it separated healthy people from those with mild cognitive impairment or Alzheimer's as verified by their brain scans. The test correctly identified 83 percent of people with high amyloid levels and correctly ruled out 85 percent of people without this condition.

"That's pretty high," the Alzheimer's Association's Carrillo said of the test's accuracy.

More importantly, she said, the Australian researchers validated the test's accuracy in two additional groups: the other 817 folks in the Australian study and 74 people in a big U.S.-led study aimed at finding novel Alzheimer's disease biomarkers.

The test performed well in those situations, too, Burnham said.

CSIRO has patented the test and is talking with major companies about making it commercially available.

"It sounds like the Australians do have good clinical data" and that the markers they are testing for track with cases of the disease, said Creighton Phelps, a neuroscientist with the U.S. National Institute on Aging.

The next step is wider validation work and ensuring it can be standardized to give reliable results regardless of what lab or doctor would use it, he said.

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Online:

National Institute on Aging: http://www.nia.nih.gov/Alzheimers

Alzheimer's Association: http://www.alz.org

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Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP



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Tuesday, July 19, 2011

Over 65 and not worried about heat? You should be (AP)

CHICAGO � This week's heat wave may be uncomfortable, but you're healthy, active and feel just fine. So what if you're over 65? Think again. Feeling good doesn't mean you're safe.

There are changes in an older person that raise the risk for heat stroke and other problems. An older body contains far less water than a younger one. Older brains can't sense temperature changes as well, and they don't recognize thirst as easily.

Blistering summer heat is an underappreciated killer, claiming by some estimates as many as 1,000 U.S. lives each year � more than any other type of weather.

One federal study found 40 percent of heat-related deaths were in people 65 and older. Those numbers could be lower if more heeded heat warnings aimed at seniors. Yet research has shown many people over 65 don't think the warnings apply to them � because they don't think they're "old."

Don Worden is 79 and an avid tennis buff who prefers playing doubles on outdoor courts along Chicago's lakefront � even in oppressive 90-degree temperatures like those hitting the Midwest this week.

"I don't pay too much attention to those" warnings, Worden said. "I stay in pretty good shape, and I don't feel they apply to me."

Worden said he drinks a lot of water and would stop a match if he started feeling effects from the heat, "but that hasn't happened."

Scott Sheridan, who studies the effects of heat and climate on health at Kent State University, researched how people over 65 view heat warnings. In his 2006 study of more than 900 people, he found about 70 percent knew about advice to drink plenty of water on very hot days, avoid outdoor activities and stay inside with air conditioning. But only about half said they followed the advice.

"People well into their 70s would say old people should watch out but not them," he said. "People just didn't want to be thought of in that same category."

Dr. David Zich, an emergency medicine specialist at Northwestern Memorial Hospital, said he has colleagues in medicine that age who shun being thought of as "elderly." But those heat warnings apply to them, too.

As Dr. William Dale, geriatrics chief at the University of Chicago Medical Center explains it, "Any older adult has less reserve and is more likely to become dehydrated than others, just because their overall body water goes down with age no matter how healthy you are."

The amount of water in the body declines with aging, from about 80 percent in young adulthood to about 55 to 60 percent for people in their 80s, Dale said.

Temperature sensors in the brain become less sensitive as people age, so the body doesn't get the same signals to drink water in hot weather, and older people often don't feel thirsty even when they need to replenish, Dale said.

They also may not feel the typical symptoms of dehydration, such as headache or dizziness. Some complain of just feeling "bad" and think they're getting sick, he said.

Conditions were ripe for those types of complaints Tuesday as a dense dome of hot air remained parked over much of the nation's midsection, raising temperatures into the mid- to upper-90s from the Texas Gulf Coast to the Rockies and the northern Plains. Tropical-level humidity raised the heat index in many places to nearly 120 degrees.

In South Dakota, up to 1,500 head of cattle died across the state from the heat. And in eastern Iowa, the scorching sun caused a portion of Interstate 380 to buckle. The weather also sent dozens of people to hospitals, canceled outdoor sporting events and caused sporadic power outages.

In such conditions, dehydration can lead to heat exhaustion and potentially deadly heat stroke. During a heat wave, that can happen in a matter of hours in older people if they over-exert themselves, don't drink enough water or are frail and don't get out of uncooled homes, said Dr. Chris Carpenter, an emergency medicine physician at Washington University School of Medicine in St. Louis.

Heat exhaustion can cause muscle cramps, low blood pressure, rapid pulse and nausea. It can be treated at home, by drinking water, getting into an air-conditioned room or sitting in front of a fan and misting the body with cool water.

But affected people should be monitored for mental changes and to make sure their temperature does not rise above 102 because the condition can quickly lead to heat stroke. A medical emergency, heat stroke involves temperatures of 104 or higher and can cause seizures, loss of consciousness and death.

Medicines many older people take also may make them more vulnerable to the heat. These include diuretics for high blood pressure, which increase urination � and make it more important to drink plenty of water, Dale said.

Some types of drugs can interfere with sweating and raise body temperature, including some medicines for insomnia, nausea, prostate conditions, Parkinson's disease and even Benadryl. Many list "dry mouth" as a side effect � a tip-off to drink more water, Zich said.

There aren't specific guidelines on how much water older people should drink in a heat wave.

Dale said he generally tells his older patients to drink a quart of water throughout the day, and to drink even if they don't feel thirsty.

Doctors also advise older patients to avoid alcohol and coffee during extreme heat because they can cause the body to lose fluid and contribute to dehydration.

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Online:

Centers for Disease Control and Prevention: http://emergency.cdc.gov/disasters/extremeheat/elderlyheat.asp

American Geriatrics Society: http://www.healthinaging.org/public_education/hot_weather_tips.php

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AP Medical Writer Lindsey Tanner can be reached at http://www.twitter.com/LindseyTanner.



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Gov't advisers: Cover birth control for free (AP)

WASHINGTON � Millions of women may soon gain free access to a broad menu of birth control methods, thanks to a recommendation issued Tuesday by health experts advising the government.

An Institute of Medicine panel recommended that the government require health insurance companies to cover birth control for women as a preventive service, without copayments. Contraception � along with such care as diabetes tests during pregnancy and screening for the virus that causes cervical cancer � was one of eight recommended preventive services for women.

President Barack Obama's health care law already requires most health plans to provide standard preventive care for people of both sexes at no additional charge to patients. The women's health recommendations were considered so sensitive that the nonpartisan institute was asked to examine the issue and report back. IOM advises the government on complex issues related to medical science and health care policy.

A half century after the introduction of the birth control pill, the IOM recommendations may help to usher in another revolution. Medical experts say easier access could start a shift to more reliable forms of long-acting birth control, such as implants or IUDs, which are gaining acceptance in other economically developed countries.

First, expect a fight over social mores. Catholic bishops and some other religious and social conservatives say pregnancy is a healthy condition and the government should not require insurance coverage of drugs and other methods that prevent it.

However, short of repealing provisions of the health care law, it's unclear what opponents can do to block the recommendations. The final decision, by Health and Human Services Secretary Kathleen Sebelius, is expected to be issued quickly.

"We are one step closer to saying goodbye to an era when simply being a woman was treated as a pre-existing condition," said Sen. Barbara Mikulski, D-Md., who sponsored the women's health amendment. "We are saying hello to an era where decisions about preventive care and screenings are made by a woman and her doctor."

Birth control use is virtually universal in the United States, according to government statistics. Generic versions of the pill are available for as little as $9 a month at big drug store chains.

Yet about half of all pregnancies are unplanned. Many occur among women using some form of contraception, and forgetting to use it is a major reason. Experts say a shift to longer acting forms of birth control would help.

Birth control is about more than sheer prevention of pregnancy � it can help make a woman's next pregnancy healthier by spacing births far enough apart, generally 18 months to two years. Research links closely spaced births to a risk of such problems as prematurity, low birthweight, even autism.

Other preventive services recommended by the IOM panel include: HIV screening; support for breast- feeding mothers, including the cost of renting pumps; counseling about sexually transmitted infections; screening for domestic violence and at least one "well-woman" preventive care visit annually.

Although the services will be free of any additional charge to patients, somebody has to pay the cost. It's likely to be spread among other people with health insurance, resulting in slightly higher premiums.



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Study: Healthy living can help prevent Alzheimer's (AP)

PARIS � Taking care of your body just might save your mind. Millions of cases of Alzheimer's disease worldwide could be prevented by curbing risk factors such as high blood pressure, smoking, obesity and lack of exercise, new research suggests.

The study offers more than the usual pep talk about healthy living. Seven conditions or behaviors account for up to half of the 35 million cases of Alzheimer's around the world, it found. With no cure or treatment to reverse the mind-robbing disease, preventing new cases is crucial.

The study was presented Tuesday at the Alzheimer's Association International Conference in France, where sessions on prevention have been drawing standing-room-only crowds for several days.

"Prevention is a particularly attractive option given the state of therapy. That's why there's so much interest in it," said William Thies, the association's chief scientific officer.

The study was led by Deborah Barnes, associate professor of psychiatry at the University of California, San Francisco. Results also were published online by the British journal Lancet Neurology. The researchers have grants from the Alzheimer's Association and the U.S. National Institutes on Aging.

The study used a mathematical model to estimate the impact of top modifiable risk factors for Alzheimer's disease: smoking, depression, low education, diabetes, too little exercise, and obesity and high blood pressure in mid-life.

How much of an impact each one has on total Alzheimer's cases depends on how common it is and how strongly it affects dementia risk. Researchers calculated the impact globally and just for the United States.

Worldwide, the biggest impact on Alzheimer's cases is low education, because illiteracy is so common, they found. Low education can be a sign of many factors that harm minds, such as poor nutrition. But it also is harmful by itself, because there is less opportunity to develop "brain power" that can carry you into old age.

"Education, even at a young age, starts to build your neural networks," so being deprived of it means less brain development, Barnes explained.

Smoking had the second biggest impact on cases worldwide, followed by too little exercise.

In the United States, however, inactivity is the leading problem because a third of the population is sedentary, Barnes said.

Depression made the next biggest impact on Alzheimer's cases in the U.S., followed by smoking and high blood pressure in mid-life. Untreated or inadequately treated depression has long been known to raise the risk of developing Alzheimer's disease.

Reducing these seven risk factors by 25 percent could mean 3 million fewer cases of Alzheimer's worldwide, including half a million in the U.S., researchers estimated. Reducing risk factors by 10 percent would translate to 1.1 million fewer cases.

"It gives us a little bit of hope about things we could do now about the epidemic that is coming our way," Barnes said.

Alzheimer's cases are expected to triple by 2050, to around 106 million worldwide.

"We can do something about this," said Dr. Ronald Petersen, a Mayo Clinic dementia specialist who had no role in the study. A common misconception is that you're "dealt a deck of cards at birth," he said, but "people need not just sit back and watch this unfold."

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Online:

National Institute on Aging: http://www.nia.nih.gov/Alzheimers

Alzheimer's Association: http://www.alz.org

Lancet: http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(11)70072-2/abstract

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Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP



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