Thursday, July 14, 2011

German farm in deadly E. coli outbreak to reopen (AP)

BERLIN � German authorities say a farm involved in a deadly E. coli outbreak is being cleared to reopen following thorough testing and the removal of all fenugreek seeds � considered the likely source.

The outbreak was traced in early June to the vegetable sprout farm at Bienenbuettel, south of Hamburg. European authorities later said one batch of fenugreek seeds from Egypt was probably the source of the bacterial outbreak that killed 53 people � 51 in Germany, and one each in Sweden and the U.S.

The state agriculture ministry in Lower Saxony said Thursday that there is no further need to keep the farm closed after negative tests on all employees and possible sources of infection there. It said all stocks of fenugreek seeds were removed from the farm.



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Movies companies snuff on-screen smoking (AP)

ATLANTA � A new study shows three film companies have drastically reduced smoking from their movies aimed at children and teens.

The three companies have in recent years adopted policies to cut on-screen tobacco use. Over the past five years, scenes involving tobacco dropped from an average of 23 to one per film and most of their youth movies had no smoking at all.

At companies without policies, the decline was less � from an average of 18 to 10 incidents per film.

In all top-grossing movies, the researchers said Thursday that smoking continued to drop last year.

Studies suggest that movies influence early decisions about smoking. Experts say the more times average teens see smoking on film, the higher the odds they will try tobacco.



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Wednesday, July 13, 2011

Doctors threaten Medicaid cutoff in Puerto Rico (AP)

SAN JUAN, Puerto Rico � Physicians are threatening to stop serving nearly a million Puerto Ricans as a result of a dispute between the island's government and an insurance company over reimbursements for treating poor people.

Gov. Luis Fortuno on Wednesday appealed to the doctors to avoid cutting off patients, saying it would be illegal. In an interview with WAPA, a local TV station, he also said the government would withhold two months of payments to the insurance company unless it settled with doctors, hospitals, laboratories and others.

Just hours after Fortuno spoke, the island's health secretary announced the government paid $57 million of the $87 million it owed Medical Card System Inc. for June. Secretary Lorenzo Gonzalez initially said the remainder would be paid only when MCS settled its bills with medical providers, but he later said it would be paid in upcoming days.

"The money is and has always been available," he said. "Our concern has been to address the complaints of providers."

Physicians say MCS owes them as much as $60 million. They plan to decide soon if they will stop stop seeing Medicaid patients until they get paid, said Dr. Joaquin Vargas, president of the Independent Practice Association, which represents 38 medical groups.

"If this payment does not occur, the services will be threatened," he said. "It is a painful situation for us."

MCS president Jose Duran said in a statement that the company will start paying providers starting Friday, but he did not specify how much of the pending debt would be paid.

The standoff began shortly after the government launched a revamped Medicaid program in October, promising patients extended hours, more access to mental health services and fewer pre-approvals required to see specialists. The program caters to those who make less than $800 a month and to the disabled.

But complaints about delayed payments began to surface in December and have increased in recent months. As a result, the government announced last week it was terminating an $810 million contract with MCS, the largest insurance provider under the revamped program.

Hospitals claim MSC owes them $91 million and pharmacies say it owes them $6 million, said Frank Diaz-Gines, executive director of the territorial Health Insurance Administration.

MCS blames the government, saying it is owed nearly $243 million for services it has provided.

The government said it owes MCS only $87.5 million for services provided before June, and most of that was for services unrelated to the new Medicaid program.

Diaz-Gines said the government will pay its $15.3 million government debt to MCS for the Medicaid program once MCS improves its services.

No problems have been reported with two other smaller health insurance companies that also provide services under the new Medicaid program.

As the standoff continues, legislators are debating a proposal to make the Health Insurance Administration or another government agency the sole payer to medical providers, eliminating involvement by insurance companies.

"We wanted to do something different after seeing that health insurance companies were having trouble," said Sen. Margarita Nolasco, the bill's co-author. "The doctors were complaining, the hospitals were complaining, the laboratories were complaining."

The Senate has approved the bill, which is now being debated by the House of Representatives.

Nolasco said eliminating the role of health insurance companies might be the solution.

"They are a business, and that is legitimate," she said. "But it cannot be done at the cost of people's health."

Fortuno, however, told reporters late Wednesday that he did not support the bill. He said the U.S. government, which provides 30 percent of the program's budget, would not allow such a change.



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Pills prevent HIV in straight men and women (AP)

ATLANTA � Two new studies found that daily pills prevented infection with the AIDS virus in heterosexual men and women in Africa, bringing new hope for someday offering a medical shield against HIV infection.

"This is good news. This is a good day for HIV prevention," said Dr. Lynn Paxton of the U.S. Centers for Disease Control and Prevention, who has coordinated the agency's research into HIV prevention.

Earlier this year, another study found the same pills did not prevent the AIDS virus among women in Kenya, Tanzania and South Africa. But researchers now say that study may have been flawed based on the success of the two studies announced Wednesday.

The first of the new studies, run by the CDC, involved more than 1,200 men and women in Botswana. About half got a daily pill, Truvada, an HIV treatment made by Gilead Sciences Inc. The other half got a fake pill.

An analysis of people who were believed to be regularly taking the pills found four of those on Truvada became infected with HIV, compared to 19 on the dummy pill. That means the real drug lowered the risk of infection by roughly 78 percent, researchers said.

The second study was funded by the Bill & Melinda Gates Foundation and run by the University of Washington. It involved more than 4,700 heterosexual couples in Kenya and Uganda. In each couple, one partner had HIV and the other did not. The uninfected were given either daily placebos, Truvada pills, or another Gilead treatment, Viread.

The study found 13 HIV infections among those on Truvada, 18 in those on Viread, and 47 of those on dummy pills. So the medications reduced the risk of HIV infection by 62 percent to 73 percent, the researchers said.

An independent review panel on Sunday said the benefit was clear-cut and stopped giving placebos, instead offering the preventive pills. Essentially, they deemed it unethical to withhold the medications from people who had been on placebo, said Dr. Jared Baeten, the University of Washington researcher who co-chaired the study.

"Our results provide clear evidence that this works in heterosexuals," he said.

In both studies, participants also were offered counseling and free condoms, which may help explain the relatively low overall infection rate.

The studies were to be announced at an AIDS conference in Rome next week. But following the recommendation of the review panel to the University of Washington study, both the CDC and the Washington team made hasty decisions to release the results.

These are the third and fourth widely reported studies of AIDS prevention medications.

The first was announced last year. It was a study of Truvada in gay men in Peru, Ecuador, Brazil, South Africa, Thailand and the United States (San Francisco and Boston). The drug lowered the chances of infection by 44 percent, and by 73 percent or more among men who took their pills most faithfully.

Experts celebrated. The CDC gave advice to doctors on prescribing Truvada along with other prevention services for gay men, based on those encouraging results.

But momentum seemed to stall in April, when an interim analysis of the study of 3,900 women in Kenya, Tanzania and South Africa did not show a benefit from taking Truvada.

Scientists are still piecing together why that study pointed to failure and the two latest indicate success. One theory is that the women in the earlier study did not take the medication as often as they should have, Paxton said.

Gilead Sciences of Foster City, Calif., is a major producer of AIDS drugs. On Tuesday, United Nations health officials announced the company had agreed to allow some of its drugs to be made by generic manufacturers, potentially increasing their availability in poor countries.



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Tuesday, July 12, 2011

Should parents lose custody of super obese kids? (AP)

CHICAGO � Should parents of extremely obese children lose custody for not controlling their kids' weight? A provocative commentary in one of the nation's most distinguished medical journals argues yes, and its authors are joining a quiet chorus of advocates who say the government should be allowed to intervene in extreme cases.

It has happened a few times in the U.S., and the opinion piece in Wednesday's Journal of the American Medical Association says putting children temporarily in foster care is in some cases more ethical than obesity surgery.

Dr. David Ludwig, an obesity specialist at Harvard-affiliated Children's Hospital Boston, said the point isn't to blame parents, but rather to act in children's best interest and get them help that for whatever reason their parents can't provide.

State intervention "ideally will support not just the child but the whole family, with the goal of reuniting child and family as soon as possible. That may require instruction on parenting," said Ludwig, who wrote the article with Lindsey Murtagh, a lawyer and a researcher at Harvard's School of Public Health.

"Despite the discomfort posed by state intervention, it may sometimes be necessary to protect a child," Murtagh said.

But University of Pennsylvania bioethicist Art Caplan said he worries that the debate risks putting too much blame on parents. Obese children are victims of advertising, marketing, peer pressure and bullying � things a parent can't control, he said.

"If you're going to change a child's weight, you're going to have to change all of them," Caplan said.

Roughly 2 million U.S. children are extremely obese. Most are not in imminent danger, Ludwig said. But some have obesity-related conditions such as Type 2 diabetes, breathing difficulties and liver problems that could kill them by age 30. It is these kids for whom state intervention, including education, parent training, and temporary protective custody in the most extreme cases, should be considered, Ludwig said.

While some doctors promote weight-loss surgery for severely obese teens, Ludwig said it hasn't been used for very long in adolescents and can have serious, sometimes life-threatening complications.

"We don't know the long-term safety and effectiveness of these procedures done at an early age," he said.

Ludwig said he starting thinking about the issue after a 90-pound 3-year-old girl came to his obesity clinic several years ago. Her parents had physical disabilities, little money and difficulty controlling her weight. Last year, at age 12, she weighed 400 pounds and had developed diabetes, cholesterol problems, high blood pressure and sleep apnea.

"Out of medical concern, the state placed this girl in foster care, where she simply received three balanced meals a day and a snack or two and moderate physical activity," he said. After a year, she lost 130 pounds. Though she is still obese, her diabetes and apnea disappeared; she remains in foster care, he said.

In a commentary in the medical journal BMJ last year, London pediatrician Dr. Russell Viner and colleagues said obesity was a factor in several child protection cases in Britain. They argued that child protection services should be considered if parents are neglectful or actively reject efforts to control an extremely obese child's weight.

A 2009 opinion article in Pediatrics made similar arguments. Its authors said temporary removal from the home would be warranted "when all reasonable alternative options have been exhausted."

That piece discussed a 440-pound 16-year-old girl who developed breathing problems from excess weight and nearly died at a University of Wisconsin hospital. Doctors discussed whether to report her family for neglect. But they didn't need to, because her medical crisis "was a wake-up call" for her family, and the girl ended up losing about 100 pounds, said co-author Dr. Norman Fost, a medical ethicist at the university's Madison campus.

State intervention in obesity "doesn't necessarily involve new legal requirements," Ludwig said. Health care providers are required to report children who are at immediate risk, and that can be for a variety of reasons, including neglect, abuse and what doctors call "failure to thrive." That's when children are severely underweight.

Jerri Gray, a Greenville, S.C., single mother who lost custody of her 555-pound 14-year-old son two years ago, said authorities don't understand the challenges families may face in trying to control their kids' weight.

"I was always working two jobs so we wouldn't end up living in ghettos," Gray said. She said she often didn't have time to cook, so she would buy her son fast food. She said she asked doctors for help for her son's big appetite but was accused of neglect.

Her sister has custody of the boy, now 16. The sister has the money to help him with a special diet and exercise, and the boy has lost more than 200 pounds, Gray said.

"Even though good has come out of this as far as him losing weight, he told me just last week, `Mommy, I want to be back with you so bad.' They've done damage by pulling us apart," Gray said.

Stormy Bradley, an Atlanta mother whose overweight 14-year-old daughter is participating in a Georgia advocacy group's "Stop Childhood Obesity" campaign, said she sympathizes with families facing legal action because of their kids' weight.

Healthier food often costs more, and trying to monitor kids' weight can be difficult, especially when they reach their teens and shun parental control, Bradley said. But taking youngsters away from their parents "definitely seems too extreme," she said.

Dr. Lainie Ross, a medical ethicist at the University of Chicago, said: "There's a stigma with state intervention. We just have to do it with caution and humility and make sure we really can say that our interventions are going to do more good than harm."

___

Online:

JAMA: http://jama.ama-assn.org

Pediatrics: http://www.pediatrics.org

___

AP Medical Writer Lindsey Tanner can be reached at http://www.twitter.com/LindseyTanner



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More AIDS patients may get cheaper drugs (AP)

LONDON � Gilead Sciences Inc. will allow some of its AIDS drugs to be made by generic manufacturers, potentially increasing their availability in poor countries, particularly in Africa, officials said Tuesday.

In the first deal of its kind, the pharmaceutical company has agreed to allow four of its AIDS drugs to be made by generic drug companies at a cheaper cost in return for a small proportion of royalties, United Nations health officials said.

Most of the 33 million people worldwide who have HIV, the virus that causes AIDS, live in Africa. One of the drugs will also be used to treat people with hepatitis.

The deal was negotiated by the Medicines Patent Pool, part of a U.N.-led partnership that raises money for AIDS, tuberculosis and malaria by things like taxing airplane tickets. Among the partnership's 29 member countries, only Chile, France, Korea, Mali and Niger are actually implementing the airline tax.

"We will continue to work with Gilead and others to expand access to all people living with HIV in developing countries," said Ellen 't Hoen, executive director of the Medicines Patent Pool.

Gilead will receive from three to five percent royalties on its four drugs, which will be supplied to about 100 countries.

Until now, its drugs have been mainly sold in rich countries, and profits from the new deal are expected to be a tiny fraction of those Gilead gets from the West.

Typically, patients in poor countries have to wait for years until the patents expire on new drugs before they can be made more cheaply by generic companies.

But some experts questioned whether the deal went far enough and pointed out it specifically excludes manufacturers in Thailand and Brazil, which both produce large amounts of generic drugs.

"This agreement is an improvement over what other big pharma companies are doing to ensure access to their patented AIDS medicines in developing countries," said Michelle Childs, a director at Doctors Without Border's campaign for access to essential medicines. Still, she warned caution was necessary and that the new deal "should not become the template for future agreements."

Other major drugmakers including Johnson and Johnson, Abbott Laboratories and Merck & Co. have so far declined to formally negotiate with the U.N.-led group.

____

Online:

http://www.unitaid.eu

http://www.msf.org.uk



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