Wednesday, October 20, 2010

'More pay' call for sperm donors

Men who donate sperm for IVF should possibly be reimbursed more than women who donate eggs, a leading fertility campaigner has suggested.

Laura Witjens, who chairs the UK's National Gamete Donation Trust and has donated her own eggs, says most people are not aware of the "serious commitment" involved in sperm donation.

She argues it is wrong to see it as less worthy than egg donation.

But fertility experts say donating eggs is invasive and carries greater risks.

Fertility clinics are not allowed to pay for eggs and sperm, but they can compensate donors up to �250 for loss of earnings plus expenses.

That limit is about to be reviewed by the fertility watchdog, the Human Fertilisation and Embryology Authority, particularly for women, who have hormone treatment and an operation to take out the eggs.

The question of reimbursement is being debated at the Royal Society of Medicine later.

Ms Witjens argues that sperm donors, who are asked to avoid sex and alcohol for several months while making regular visits to a clinic, should receive "at least the same payment if not more than egg donors".

'Heroes'

In an article for the BBC News website's "Scrubbing Up" column, she says it is wrong that most attention is paid to egg donors who enjoy "elevated status", while sperm donors may be subjected to "jokes or smutty comments".

"Assuming [sperm donors] follow the guidelines, it means we're asking healthy men aged between 20 and 45 (and their partners) to have very limited sexual activity for months on end. This has a significant impact on their normal life," Ms Witjens writes.

"Just like egg donors, to the families these guys help, they are heroes. And that's something that deserves recognition from us all."

She acknowledges that donating eggs involves risks and is much more intrusive; 10 years ago she donated her own eggs for use in IVF treatment.

But Ms Witjens concludes that payment should not be based solely on medical risk, and that sperm donors should be rewarded for their "commitment, dedication and selflessness".

Many fertility experts disagree with higher reimbursement for sperm donors.

Dr Allan Pacey, a senior lecturer in andrology at Sheffield University, says he is personally uncomfortable with the debate over money, arguing that "the clue is in the name - donations".

But he says: "We have argued historically that women should be paid more because they take more risk."

'Woefully inadequate'

However, he agrees that sperm donors are not treated well enough. "In society we tend to sneer. That chips away at potential donors."

Sarah Norcross, director of Progress Educational Trust, also disagrees with the idea of offering more for sperm donors, arguing that women face a "much more intrusive procedure".

She said: "There's always a risk attached, much higher than for a man turning up and doing the business in a jar."

However she agrees that the level of compensation for men and women should increase, describing the current limit as "woefully inadequate".



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'Tipsy' alcohol gene discovered

Experts say they have found a "tipsy" gene that explains why some people feel alcohol's effects quicker than others.

The US researchers believe 10% to 20% of people have this gene - called CYP2E1 - and that it may offer some protection against alcoholism.

That is because people who react strongly to alcohol are less likely to become addicted, studies show.

The University of North Carolina said the study aims to help fight addiction, not pave the way for a cheap night out.

Ultimately, people could be given CYP2E1-like drugs to make them more sensitive to alcohol - not to get them drunk more quickly, but to put them off drinking to inebriation, the Alcoholism: Clinical and Experimental Research journal reported.

Straight to the head

Lead researcher Professor Kirk Wilhelmsen said: "Obviously we are a long way off having a treatment, but the gene we have found tells us a lot about how alcohol affects the brain."

Most of the alcohol people consume is broken down in the liver, but some is metabolised in the brain by an enzyme which the CYP2E1 gene provides coded instructions for.

"Start Quote

Alcoholism is a very complex disease, and there are lots of complicated reasons why people drink. This may be just one of the reasons"

End Quote Professor Kirk Wilhelmsen, who led the research

People who have the "tipsy" version of CYP2E1 break down alcohol more readily, which explains why they feel the effects of alcohol much quicker than others.

The researchers made their discovery by studying more than 200 pairs of students who were siblings and who had one alcohol-dependent parent but who did not have a drink problem themselves.

They gave the students a mixture of grain alcohol and soda that was equivalent to about three average alcoholic drinks. At regular intervals the students were then asked whether they felt drunk, sober, sleepy or awake.

The researchers then compared the findings with gene test results from the students.

This revealed that CYP2E1 on chromosome 10 appears to dictate whether a person can hold their drink better than others.

Professor Wilhelmsen says more research is now needed to see if the findings could be used to make new treatments to tackle alcohol addiction.

"Alcoholism is a very complex disease, and there are lots of complicated reasons why people drink. This may be just one of the reasons," he added.

Don Shenker, of the charity Alcohol Concern, said that, in most cases, alcohol abuse stemmed from social problems, with alcohol used as a prop.

Professor Colin Drummond, an expert in addiction at London's Institute of Psychiatry, said it was likely to be combination of genes and environment.

"It is well recognised that alcohol dependence runs in families," he said.

He said research suggests having an alcoholic parent quadruples a person's risk of developing a drinking problem.



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